Epithelial Chloride Channel Development of lnhibitory Ligands
نویسنده
چکیده
I N T R O D U C T I O N Chloride channels are present in the plasma membranes o f epithelia (Frizzell et al., 1981), nerve (Hamill et al., 1983), and muscle (Blatz and Magleby, 1985), as well as in intraceilular membranes such as Golgi apparatus (Glickman et al., Address reprint requests to Dr. Qais AI-Awqati, Depts. of Medicine and Physiology, College of Physicians and Surgeons, Columbia University, 630 W. 168th St., New York, NY 10032. j. GEN. PHYSIOL. ~) The Rockefeller University Press 9 0022-1295/87/12/0779/20 $2.00 Volume 90 December 1987 779-798 779 on Jne 9, 2017 D ow nladed fom Published December 1, 1987
منابع مشابه
Epithelial chloride channel. Development of inhibitory ligands
Chloride channels are present in the majority of epithelial cells, where they mediate absorption or secretion of NaCl. Although the absorptive and secretory channels are well characterized in terms of their electrophysiological behavior, there is a lack of pharmacological ligands that can aid us in further functional and eventually molecular characterization. To obtain such ligands, we prepared...
متن کاملEG-VEGF, BV8, and their receptor expression in human bronchi and their modification in cystic fibrosis: Impact of CFTR mutation (delF508).
Enhanced lung angiogenesis has been reported in cystic fibrosis (CF). Recently, two highly homologous ligands, endocrine gland vascular endothelial growth factor (EG-VEGF) and mammalian Bv8, have been described as new angiogenic factors. Both ligands bind and activate two closely related G protein-coupled receptors, the prokineticin receptor (PROKR) 1 and 2. Yet, the expression, regulation, and...
متن کاملEGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
Particulate atmospheric pollutants interact with the human airway epithelium, which releases cytokines, chemokines, and EGF receptor (EGFR) ligands leading to proinflammatory responses. There is little information concerning the short-term effects of EGFR activation by extracellular ligands on ionic regulation of airway surface lining fluids. We identified in the membrane of human epithelial br...
متن کاملRegulation of CFTR chloride channel trafficking by Nedd4-2: role of SGK1
Introduction: The cystic fibrosis transmembrane conductance regulator (CFTR) chloride (Cl−) channel is an essential component of epithelial Cl− transport systems in many organs. CFTR is mainly expressed in the lung and other tissues, such as testis, duodenum, trachea and kidney. The ubiquitin ligase neural precursor cells expressed developmentally down-regulated protein 4-2 (Nedd4-2...
متن کاملEGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o : involvement of tyrosine kinase p60
Jeulin C, Seltzer V, Bailbé D, Andreau K, Marano F. EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o : involvement of tyrosine kinase p60. Am J Physiol Lung Cell Mol Physiol 295: L489–L496, 2008. First published June 27, 2008; doi:10.1152/ajplung.90282.2008.—Particulate atmospheric pollutants interact with the human airway epitheliu...
متن کامل